Transcription factors are key cellular components that control gene expression their activities determine how cells function and respond to the environment currently there is great interest in research into human transcriptional regulation however surprisingly little is known about these . Identification of the entire cohort of transcription factors required for eye development is an essential first step towards understanding the mechanisms underlying eye morphogenesis and differentiation and the molecular basis of inherited eye abnormalities in humans. The human transcription factors samuel lambert 1 arttu jolma 2 1 department of molecular genetics university of toronto toronto on canada transcription factors tfs recognize specific dna sequences to control chromatin and transcription forming a complex system that guides expression of the genome . Human molecular genetics transcription factors transcription factors two components of the basal transcription machinery the prb family of proteins the e2f transcription factor c myc transcription factor and its partners role of p53 as transcription factor and growth suppressor chimeric transcription factors in human leukemias
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